What's new
DPIM co-affinity prufication complex data
Protein interactions determined in large-scale co-affinity purification (co-AP)/MS screens by the Drosophila Protein Interaction Mapping (DPIM) project, a collaboration among the laboratories of Spyros Artavanis-Tsakonsa, Steven Gygi , Susan Celniker, and K. VijayRaghavan (DPIM web site). See DroID database description page for more details.
Functional Genomics of RTK/Ras/ERK Signaling
Protein interaction data and RNAi phenotype data from the Perrimon Lab (Friedman et al., Science Signaling 25 October 2011). Co-affinity purification and MS was used to create a dynamic protein interaction map centered on 15 conserved canonical components of the receptor tyrosine kinase and Ras/ERK signaling pathways under baseline conditions and after insulin or EGF treatment. Genome-wide RNAi screens were also conducted under similar conditions. The interaction network and RNAi data cab be simultaneously searched, visualized, filtered, and combined with other DroID data using a new beta version of IM Browser.
Gene expression data from modENCODE
With DroID v2011_02, interaction data can now be searched or filtered using RNA-Seq data from modENCODE. The quantitative RNA expression data is from 30 developmental time points. See the database description page for more info.
Phenotype and gene expression data from Flybase
With DroID v2011_02, interaction data can also be searched and filtered using phenotype data and RNA and protein expression data. The data are from Flybase and use controlled vocabularies. See the database description page for more info.
Transcription factor - Gene interactions
First added in DroID v2010_08, TF-Gene interactions now include data from REDFly and modENCODE. See the database description page for more info.
miRNA - Gene interactions
First added in DroID v2010_08, miRNA-Gene interactions now include predictions from TargetScanFly, MinoTar, and modENCODE .See the database description page for more info.
